Correlación de los días de estancia hospitalaria con el índice neutrófilo-linfocítico en pacientes con diagnóstico de angina de Ludwig / Correlation of the days of hospital stay with the neutrophillymphocyte ratio in patients with a diagnosis of Ludwig's angina: pilot study

Introducción: El objetivo del presente estudio es correlacionar los días de estancia hospitalaria con el índice neutrófilo-linfocitico (INL) como biomarcador, en los pacientes con diagnóstico de angina de Ludwig que fueron admitidos en urgencias. Pacientes y métodos: Se realizó una búsqueda en los expedientes clínicos del hospital, donde solo se obtuvieron los que tenían diagnóstico de angina de Ludwig desde junio de 2016 hasta junio de 2020, y que cumplieran con los criterios de selección. Posteriormente se recabaron los datos sociodemográficos, días de hospitalización, biometría hemática y valores de neutrófilos y linfocitos para su posterior análisis estadístico. Resultados: Obtuvimos 21 pacientes (9 mujeres y 12 hombres). La edad promedio fue de 43,1 años (rango: 27-70 años). Se transformó la variable de días de hospitalización: en corta estancia hospitalaria aquellos pacientes que estuvieron hospitalizados 5 días o menos; y los de larga estancia hospitalaria aquellos pacientes que estuvieron hospitalizados 6 días o más, para el INL se consideró un índice alto aquellos pacientes que se encontraran con un INL ≥ 6 y un índice bajo aquellos pacientes con un índice ≤ 5, tomando en cuenta el punto de corte con respecto a estudios previamente realizados. Se observó que aquellos pacientes con un INL alto tuvieron una estancia hospitalaria larga, y de acuerdo con los resultados obtuvimos significación estadística (p = 0,02). Conclusiones: El INL parece ser un buen biomarcador para predecir los días de estancia hospitalaria de los pacientes con angina de Ludwig. Sin embargo, se necesitan más estudios para confirmar nuestros resultados. (AU)

Introduction: The aim of this study is to correlate the number of days of hospital stay with the neutrophil-lymphocyte index (NLI) as a biomarker in patients diagnosed with Ludwig's angina who were admitted to the emergency department. Patients and methods: A search was conducted in the hospital's medical records, where only those with a diagnosis of Ludwig's angina from June 2016 to June 2020 and that met the selection criteria were obtained. Afterwards, sociodemographic data, days of hospitalization, hematological parameters, and values of neutrophils and lymphocytes were collected for subsequent statistical analysis. Results: We obtained 21 patients (9 females and 12 males). The average age was 43.1 years (range: 27-70 years). The variable of days of hospitalization was transformed into: short hospital stay for patients who were hospitalized for 5 days or less, and long hospital stay for patients who were hospitalized for 6 days or more. For the NLI, a high index was considered for patients with an NLI ≥ 6 and a low index for patients with an NLI ≤ 5, taking into account the cut-off point with respect to previously conducted studies. We observed that patients with a high NLI had a long hospital stay and according to the results, we obtained statistical significance (p = 0.02). Conclusions: The NLI appears to be a good biomarker for predicting the number of days of hospital stay for patients with Ludwig's angina. However, more studies are needed to confirm our results. (AU)

Angina de Ludwig / Angina de Ludwig / Ludwig Angina

Introducció. L’angina de Ludwig és un procés infecciós ràpidament progressiu a l’espai submandibular relacionatamb infeccions odontogèniques preexistents. La tomografiacomputada (TC) és útil per definir-ne la localització i l’extensió. Un diagnòstic i un maneig precoços són importantsper evitar complicacions potencialment greus com l’obstrucció de la via aèria.Cas clínic. Adolescent de 14 anys que consulta per odontàlgia amb tumefacció submandibular dolorosa, sialorrea,trisme i disfàgia de 48 hores d’evolució, sense febre associada. Presenta càries en peces dentàries 46-48 i tumescència submandibular dreta, dura i dolorosa al tacte, quesobrepassa la línia mitjana, amb eritema, edema i calor. Alcap de 24 hores d’iniciar l’antibioteràpia, davant l’augmentde la tumefacció i l’empitjorament analític, es fa una TCcervical en què s’objectiva una col·lecció compatible ambabscés al terra de la boca. Es modifica el tractament antibiòtic, s’hi afegeix corticoteràpia i es deriva a cirurgia maxil·lofacial per a tractament quirúrgic.Comentaris. L’angina de Ludwig és una infecció greu delterra de la boca que cal considerar en el diagnòstic diferencial d’una infecció periodontal amb tumefacció submandibular. És de vital importància conèixer-ne les manifestacions locals i sistèmiques per actuar precoçment. (AU)

Introducción. La angina de Ludwig es un proceso infeccioso rápidamente progresivo en el espacio submandibular relacionado coninfecciones odontogénicas preexistentes. La tomografía computarizada (TC) es útil para definir su localización y extensión. Undiagnóstico y manejo precoces son importantes para evitar complicaciones potencialmente graves, como la obstrucción de la víaaérea.Caso clínico. Adolescente de 14 años que consulta por odontalgiacon tumefacción submandibular dolorosa, sialorrea, trismo y disfagia de 48 horas de evolución, sin fiebre asociada. Presenta cariesen piezas dentales 46-48 y tumescencia submandibular derecha, dura y dolorosa al tacto, que sobrepasa la línea media, con eritema, edema y calor. A las 24 horas de iniciar antibioterapia, dadoel aumento de la tumefacción y empeoramiento analítico, se realiza una TC cervical donde se objetiva una colección compatiblecon absceso en el suelo de la boca. Se modifica el tratamientoantibiótico, se añade corticoterapia y se deriva a cirugía maxilofacial para tratamiento quirúrgico. (AU)

Introduction. Ludwig angina is a rapidly progressive infectious process of the submandibular space related to pre-existing odontogenic infections. Computed tomography (CT) is useful to define thelocation and extent. Early diagnosis and management are important to avoid potentially serious complications such as airway obstruction.Case report. A 14-year-old girl presented to the emergency roomwith a 48-hour history of toothache and submandibular swelling,sialorrhea, trismus and dysphagia without associated fever. Physical examination showed caries in teeth number 46-48 and rightsubmandibular tumescence, hard and painful to the touch, whichcrossed the midline, with erythema, edema and heat. Twenty-fourhours after starting antibiotic therapy, given the worsening clinicalcondition and laboratory findings, a cervical CT scan was performed, which showed a collection compatible with abscess in thefloor of the mouth. The antibiotic therapy was changed, corticoidswere added, and the patient was referred to maxillofacial surgeryfor surgical treatment.Comments. Ludwig angina is a serious infection of the floor of themouth that should be considered in the differential diagnosis ofperiodontal infection with submandibular swelling. It is very important to know its local and systemic manifestations for an earlyintervention. (AU)

Angina de Ludwig, aspectos semiológicos útiles para el diagnóstico presuntivo de una patología letal / Ludwig`s angina, useful semiologic points for the presumptive diagnosis of a lethal pathology

Resumen Mujer de 74 años consulta al servicio de urgencia por cuadro de sepsis origen aparentemente no precisado, hasta su evaluación por dermatología que describe eritema violáceo cervical anterior más una infección en cavidad bucal como puerta de entrada. Considerando la clínica y los estudios por imágenes confirmamos el diagnóstico de Angina de Ludwig, cuadro de alta morbimortalidad que puede progresar a otras complicaciones más graves. Finalmente la paciente evoluciona de manera tórpida no respondiendo a medidas realizadas de soporte y fallece. La Angina de Ludwig es una celulitis de evolución rápida y grave, muy poco frecuente, que por lo general tiene una puerta de entrada a través de infecciones de la mucosa oral, donde su sospecha obliga a iniciar terapia precoz con antibióticos, quirúrgico y soporte.

Abstract This is a 74-year-old female patient with comorbidities who consulted the emergency service due to symptoms of sepsis of apparently unspecified origin, until her evaluation by dermatology revealed mild anterior cervical violaceous erythema and probable dental infection as the portal of entry. Based on clinical and imaging findings, a diagnosis of Ludwig's angina is confirmed, a condition with high morbidity and mortality that can progress to other more severe complications. Finally, the patient had a torpid evolution, not responding to support measures, and died. Ludwig's Angina is a cellulitis of etiology, usually rapidly progressive, infrequent oral infections, where a mandatory physical examination should be considered and suspected in order to start early therapy.

Análise de prontuários de pacientes com infecções odontogênicas atendidos no serviço hospitalar / Análisis de registros de pacientes con infecciones dentales atendidos en el servicio de hospital / Analysis of records of patients with dental infections care at the hospital service

Objetivo: O seguinte estudo é uma análise de prontuários para traçar um perfil epidemiológico de pacientes acometidos por infecções odontogênicas e/ou angina de Ludwig em um serviço hospitalar público. Metodologia: Foi realizado um estudo observacional de 37 prontuários com diagnóstico de infecção odontogênica e/ou Angina de Ludwig no Hospital da Restauração, na cidade do Recife, Pernambuco, entre os meses de julho a novembro de 2021. Resultados: Dos 37 prontuários, a maioria foi do sexo masculino (55%; n=20), a faixa etária mais acometida foi dos 18 aos 40 (45%; n=17); abaixo dos 10 anos foram acometidos 27% (n = 10). 21% (n = 8) foram internados e dos 37 prontuários, 13% (n = 5) evoluíram para Angina de Ludwig. Conclusão: O perfil mais acometido por infecções odontogênicas no período proposto foram pacientes do sexo masculino adultos e a internação não prevaleceu na maioria dos casos. O alto acometimento de crianças é um sinal de alerta, sugerindo uma atenção maior dos responsáveis. A angina de Ludwig acometeu menos da metade dos pacientes e a Ceftriaxona e o Metronidazol foram os antibióticos de escolha para a maioria dos casos... (AU)

Objetivo: El siguiente estudio es un análisis de historias clínicas para trazar un perfil epidemiológico de los pacientes afectados por infecciones odontogénicas y/o angina de Ludwig en un servicio hospitalario público. Metodología: Se realizó un estudio observacional en 37 historias clínicas con diagnóstico de infección odontogénica y/o Angina de Ludwig en el Hospital da Restauração, en la ciudad de Recife, Pernambuco, entre julio y noviembre de 2021. Resultados: De las 37 historias clínicas, la mayoría eran hombres (55%; n=20), el grupo de edad más afectado fue el de 18 a 40 años (45%; n=17); menores de 10 años, el 27% (n = 10) estaban afectados. El 21% (n = 8) fueron hospitalizados y de las 37 historias clínicas, el 13% (n = 5) progresó a Angina de Ludwig. Conclusión: El perfil más afectado por infecciones odontogénicas en el periodo propuesto fueron pacientes adultos del sexo masculino y no predominó la hospitalización en la mayoría de los casos. La alta participación de los niños es una señal de advertencia, lo que sugiere una mayor atención por parte de los responsables. La angina de Ludwig afectó a menos de la mitad de los pacientes y la ceftriaxona y el metronidazol fueron los antibióticos de elección en la mayoría de los casos... (AU)

Objective: The following study is an analysis of medical records to trace an epidemiological profile of patients affected by odontogenic infections and/or Ludwig's angina in a public hospital service. Methodology: An observational study was carried out on 37 medical records with a diagnosis of odontogenic infection and/or Ludwig's Angina at Hospital da Restauração, in the city of Recife, Pernambuco, between July and November 2021. Results: Of the 37 medical records, the most were male (55%; n=20), the age group most affected was from 18 to 40 (45%; n=17); under 10 years of age, 27% (n = 10) were affected. 21% (n = 8) were hospitalized and of the 37 medical records, 13% (n = 5) progressed to Ludwig's Angina. Conclusion: The profile most affected by odontogenic infections in the proposed period were adult male patients and hospitalization did not prevail in most cases. The high involvement of children is a warning sign, suggesting greater attention from those responsible. Ludwig's angina affected less than half of the patients and Ceftriaxone and Metronidazole were the antibiotics of choice for most cases... (AU)

Angina de Ludwig durante el embarazo. Reporte de caso / Ludwig's angina during pregnancy. Case report

RESUMEN Los cambios fisiológicos, hormonales e inmunes causados por el embarazo pueden predisponer a mayor riesgo de complicaciones infecciosas, en especial en infecciones odontogénicas. La angina de Ludwig es una complicación infecciosa rápidamente progresiva que afecta al suelo de la cavidad bucal, generalmente secundaria a abscesos de segundos y terceros molares mandibulares que posteriormente se extiende a los espacios submandibular, sublingual y submentoniano. Si no es tratada rápida y adecuadamente puede tener consecuencias mortales, como obstrucción de las vías aéreas altas y sepsis. Su aparición durante el embarazo está asociada a mayor riesgo de morbilidad perinatal severa, en la mayoría de los casos secundaria a hipoxia tisular. El tratamiento es la administración de antibióticos de amplio espectro y, en algunos casos, descompresión quirúrgica de las zonas afectadas. Pero es necesario considerar los potenciales efectos adversos fetales del manejo. Es fundamental reforzar la importancia de la buena salud bucodental de la embarazada para evitar esta complicación. Se presenta un caso de angina de Ludwig durante el embarazo.

ABSTRACT Physiological, hormonal and immune changes caused by pregnancy may predispose to increased risk of infectious complications, especially in odontogenic infections. Ludwig's angina is a rapidly progressive infectious complication affecting the floor of the oral cavity, usually secondary to abscesses of mandibular second and third molars that subsequently spreads to the submandibular, sublingual and submental spaces. If not treated quickly and adequately it can have fatal consequences, such as upper airway obstruction and sepsis. Its occurrence during pregnancy is associated with an increased risk of severe perinatal morbidity, in most cases secondary to tissue hypoxia. Treatment consists of the administration of broad-spectrum antibiotics and, in some cases, surgical decompression of the affected areas. But it is necessary to consider the potential adverse fetal effects of management. It is essential to reinforce the importance of good oral health of the pregnant woman to avoid this complication. A case of Ludwig's angina during pregnancy is presented.

Mediastinitis descendente en el contexto de la angina de Ludwig. Artículo de revisión / Descending mediastinitis in the context of Ludwig's Angina. Article review

Introducción: la mediastinitis se define como el proceso inflamatorio usualmente infeccioso del tejido conectivo mediastinal y los órganos que este rodea. Específicamente, la mediastinitis descendente corresponde a una complicación rara por infección de los espacios profundos del cuello, la orofaringe o la cavidad oral, que se extiende a través de los espacios fasciales del cuello y los diseca. De forma infrecuente, esta patología puede originarse a partir de la parotiditis, las infecciones de la piel del cuello o la epiglotitis. También, de manera menos frecuente, puede generarse en el contexto de un traumatismo del cuello o la cavidad oral. En este estudio se pretende llamar la atención, en particular, sobre los aspectos que involucran al especialista otorrinolaringólogo en el manejo de los pacientes con infecciones profundas del cuello y su rol en el diagnóstico y tratamiento eficaz de la mediastinitis descendente, como la principal causa de mortalidad en estos casos. Metodología: se llevó a cabo una búsqueda con las palabras clave "Airway" "Ludwig's angina" en PubMed, no se efectuó filtración por fecha ni tipo de estudio. Se encontró un total de 147 artículos. Se realizó lectura de los resúmenes por los autores y se seleccionaron 50. Se realizó lectura crítica del texto completo de los 50 artículos resultantes de la búsqueda y se extrajo la información relevante. Conclusión: esta patología de marcada severidad conlleva a un aumento significativo de la mortalidad. Su tratamiento, aunque permanece controversial en ciertas circunstancias, debe ser agresivo y oportuno, con un enfoque en el rol del otorrinolaringólogo en 4 pilares de tratamiento: el drenaje quirúrgico, la antibioticoterapia de amplio espectro, el soporte hemodinámico y la seguridad de la vía aérea.

Introduction: Mediastinitis is defined as the usually infectious inflammatory process of the mediastinal connective tissue and the organs it surrounds. Specifically, descending mediastinitis corresponds to a rare complication, an infection of deep spaces of the neck, oropharynx, or oral cavity, which extends through the facial spaces of the neck, dissecting. Less frequent, this pathology can originate from parotiditis, skin infections of the neck or epiglottitis. Also, less frequent it can be generated in the context of trauma to the neck or oral cavity. This study intends to draw attention to the aspects that involve the ENT specialist in the management of patients with deep neck infections and their role in the diagnosis and effective treatment of descending mediastinitis as the main cause of mortality in these patients. Methodology: A search was carried out with the keywords "Airway" "Ludwig's angina" in PubMed, no filtering was performed by date or type of study, finding a total of 147 articles, abstracts were read by the authors, selecting 50. A critical reading of the 50 articles full texts is carried out and the relevant information is extracted. Conclusion: This pathology of marked severity, carries a significant increase in mortality and its treatment, although it remains controversial in certain circumstances, it must be aggressive and timely, focusing the role of the otorhinolaryngologist on 4 pillars of treatment: surgical drainage, antibiotic therapy, hemodynamic support, and airway safety.

Angina de Ludwig en la paciente embarazada. Reporte de un caso / Ludwig's angina in the pregnant patient. A case report

Resumen: Introducción: La angina de Ludwig es una patología odontogénica de origen infeccioso que involucra los espacios submaxilar, sublingual y submentoniano y que compromete de forma notable la vía aérea. El mantenimiento de las vías respiratorias debe ser prioridad en el tratamiento de esta patología, ya que la asfixia por obstrucción es la primera causa de muerte en un primer momento. Caso clínico: Paciente de 22 años de edad con embarazo de 35.5 SDG con amenaza de parto pretérmino más angina de Ludwig, a la cual se le realizó cesárea Kerr y drenaje de absceso profundo de cuello bajo anestesia regional y anestesia general balanceada con intubación con paciente despierta. Discusión: La angina de Ludwig debido a la distorsión anatómica condiciona vía aérea difícil y esto se exacerba aunado al embarazo a causa de los cambios anatómicos que ocurren, lo que nos obliga a la intubación endotraqueal con la paciente despierta de primera intención para asegurar la vía aérea.

Abstract: Introduction: Ludwig's angina is an odontogenic pathology of infectious origin that involves the submaxillary, sublingual and submental spaces and that significantly com-promises the airway. The maintenance of the respiratory tract must be a priority in the treatment of this pathology since asphyxia by obstruction is the first cause of death at first. Case report: A 22-year-old patient with a 35.5 SDG pregnancy plus preterm labor threat plus Ludwig's angina, who underwent cesarean Kerr and deep neck abscess drainage under regional anesthesia plus balanced general anesthesia with intubation with awake patient. Discussion: Ludwig's angina due to anatomical distortion conditions difficult air-way and this together with pregnancy exacerbates it due to the anatomical changes that exist in it, it forces us to endotracheal intubation with the awake patient of first intention to ensure the pathway aerial.

Mediastinitis necrotizante descendente de origen odontogénico / Descending necrotizing mediastinitis of odontogenic origin

Introducción: las infecciones odontogénicas afectan al 80 %-90 % de la población y pueden dar lugar a complicaciones potencialmente mortales como la mediastinitis necrotizante descendente, una infección polimicrobiana aguda en el mediastino con una tasa de mortalidad entre el 11 % y 40 %. Su detección precoz y el tratamiento adecuado con manejo antibiótico y drenaje quirúrgico a cargo de un equipo multidisciplinario representan factores influyentes en el pronóstico de la enfermedad. Objetivo: en este artículo presentamos un caso de mediastinitis necrotizante descendente en un paciente masculino de 34 años, que se originó por una infección odontogénica que requirió un procedimiento dental. El paciente fue hospitalizado por el empeoramiento del estado clínico a pesar de la profilaxis antibiótica. La tomografía axial computarizada (TAC) confirmó la extensión de la infección al mediastino, y el paciente fue tratado con éxito con antibioterapia intravenosa y múltiples drenajes quirúrgicos intraorales, cervicotomía y toracoscopia. Materiales y métodos: se realizó una búsqueda en bases de datos globales y se seleccionaron los artículos por los siguientes términos MeSH y DeCS: "mediastinitis necrotizante descendente", "angina de Ludwig", "absceso", "toracoscopia" y sus respectivos en inglés, priorizando los referentes a la mediastinitis necrotizante descendente de origen odontogénico. Conclusiones: en la mediastinitis necrotizante descendente, la combinación de diagnóstico precoz, tratamiento antibiótico de amplio espectro, mantenimiento de la vía aérea y drenaje quirúrgico amplio y a cargo de un equipo multidisciplinario mejora de manera importante el pronóstico de la enfermedad.

Introduction: Odontogenic infections affect 80%-90% of the population and can lead to life-threatening complications such as descending necrotizing mediastinitis. Is an acute polymicrobial infection in the mediastinum with a mortality rate of 11%-40%. Its early detection and adequate treatment with antibiotic management and surgical drainage by a multidisciplinary team represent influential factors in the prognosis of the disease. Objective: In this article, we present a case of descending necrotizing mediastinitis in a 34-year-old male patient that originated from an odontogenic infection that required a dental procedure. The patient was hospitalized for worsening clinical status despite antibiotic prophylaxis. Computed axial tomography confirmed the extension of the infection to the mediastinum and the patient was successfully treated with intravenous antibiotherapy and multiple intraoral, cervicotomy, and thoracoscopic surgical drains. Materials and methods: A search was made in global databases, articles were selected by the following MeSH and DeCS terms: "descending necrotizing mediastinitis", "Ludwig's angina", "abscess", "thoracoscopy", and their respective English terms, prioritizing those referring to descending necrotizing mediastinitis of odontogenic origin. Conclusions: In descending necrotizing mediastinitis, the combination of early diagnosis, broad-spectrum antibiotic treatment, airway maintenance, and extensive surgical drainage by a multidisciplinary team significantly improves the prognosis of the disease.

Angina de ludwig de foco amigdaliano evoluindo para mediastinite - Um caso de sucesso / Amigdalian focus of ludwig's angina expanding to mediastinitis - A success case

Objetivo: relatar e descrever a evolução satisfatória de uma Angina de Ludwig decorrente de uma infecção amigdaliana, que evoluiu para mediastinite e choque séptico. O trabalho visa detalhar os aspectos clínicos e diagnósticos desta grave doença, além da terapêutica empregada neste caso. Método: as informações foram obtidas do prontuário do paciente, bem como dos laudos dos exames de imagem realizados. A revisão da literatura foi feita na base de dados PUBMED. Considerações finais: o caso estudado relata um raro desfecho favorável de uma Angina de Ludwig que evoluiu para mediastinite, cuja taxa de mortalidade é de até 50% dos casos. A abordagem cirúrgica combinada com antibioticoterapia precoce se mostra ser a melhor conduta para estes casos.

Objective: report and describe the satisfactory evolution of Ludwig's Angina due to a tonsillary infection, which evolved to mediastinitis and sept shock. The work aims to detail the clinical and diagnostic aspects of this serious illness, in addition to the therapy used in this case. Method: the information was obtained from the patient's medical record, as well as from the reports of the imaging tests performed. The literature review was carried out in the PUBMED database. Final considerations: the case studied has great importance for the medical community, since it reports a rare favorable outcome for a case of Ludwig's Angina complicated with an mediastinitis, whose mortality is described up to 50% of the cases. The surgical approach combined with early antibiotic therapy is shown to be the best approach for these cases.

Angina de Ludwig complicada con shock séptico / Ludwig´s angina complicated with septic shock

Introduction: Ludwig's angina is one of the soft tissue infections of the neck and tongue floor with the most admissions to intensive care units (ICU) due to its compromise of the airway and complications from septic shock. The incidence is higher in the adult population, and with the use of the latest generation antibiotics, its incidence has decreased. One of the most frequent causes is the presence of an odontogenic focus such as abscesses, mainly in the second and third molars. Objective: To describe a clinical case, admitted to the hospital ICU, highlighting the comprehensive management and adequate antibiotic therapy. Main data of the case: 24-year-old female patient, a native of Latacunga, went to the emergency service of the Hospital del Sur de Quito for a fever of 10 days of evolution and taking the general condition with signs of shock, and intense pain in the tongue, with edema, and impaired phonation. For initial management, intravenous tramal, IV hydrocortisone, and a broad spectrum antibiotic with piperacillin with tazobactam 4 grams IV every 6 hours, and IV metronidazole every 8 hours. Conclusions: Ludwig's angina is a pathology that usually involves young patients, whose evolution is rapid and its inadequate management leads to death, associated with obstructive respiratory failure and severe sepsis, which requires a timely diagnosis.

Introducción: La angina de Ludwig constituye una de las infecciones de los tejidos blandos del cuello y piso de la lengua con más ingresos en las unidades de cuidados intensivos (UCI) por su compromiso de la vía aérea y complicaciones por shock séptico. La incidencia es mayor en la población adulta, y con el uso de los antibióticos de última generación, su incidencia ha disminuido. Una de las causas más frecuentes es la presencia de un foco odontogénico como los abscesos, principalmente en el segundo y el tercer molar. Objetivo: Describir un caso clínico, internado en la UCI del hospital, destacando el manejo integral y la terapia antibiótica adecuada. Datos principales del caso: paciente femenina de 24 años, natural de Latacunga, acude al servicio de emergencias del Hospital del sur de Quito por fiebre de 10 días de evolución y toma del estado general con signos de shock, y dolor intenso en lengua, con edema, y deterioro de la fonación. Para el abordaje inicial se administra tramadol por vía intravenosa (IV), hidrocortisona IV y antibiótico de amplio espectro con piperacilina con tazobactam 4 gramos IV cada 6 horas, y metronidazol IV cada 8 horas. Conclusiones: la angina de Ludwig es una afección que habitualmente involucra pacientes jóvenes, cuya evolución es rápida y su inadecuado abordaje conlleva a la muerte, asociado con insuficiencia respiratoria obstructiva y sepsis grave, por lo que requiere un diagnóstico oportuno

Mediastinite descendente necrosante pós-angina de Ludwig: relato de caso / Descending necrotizing mediastinitis after Ludwig's angina: case report

Introdução: a mediastinite necrosante descendente é um processo infeccioso grave do mediastino e pode ser originária de uma infecção odontogênica, apresentando; alta taxa de mortalidade. O cirurgião-dentista deve buscar estratégias para prevenir focos infecciosos, diminuindo a incidência de infecções odontogênicas graves que se disseminem pelos espaços cervicofaciais e torácicos. Objetivo: relatar caso de um paciente com diagnóstico de mediastinite necrosante pós-angina de Ludwig, descrever suas manifestações clínicas e a conduta terapêutica odontológica adotada. Relato de caso: paciente, 31 anos, sexo masculino, foi admitido referindo sintomatologia dolorosa no dente 3.8, que evoluiu para aumento de volume em região cervical, associado à febre e disfagia progressiva. Ao exame físico extraoral, observam-se sinais de disseminação para os espaços cervicofaciais e torácicos. Após exames complementares, o diagnóstico revela a infecção, associada à angina de Ludwig, secundária à pericoronarite. O tratamento foi analgesia e antibioticoterapia por via venosa. Após remissão dos sintomas, o paciente recebeu alta hospitalar em bom estado e foi realizada exodontia do dente 3.8. Conclusão: a mediastinite necrosante é uma patologia rara que pode levar a óbito, se não tratada adequadamente. O cirurgiãodentista deve estar consciente da possibilidade de disseminação pelos espaços faciais e mediastinais dos processos infecciosos de origem odontogênica e estar apto para tratar corretamente os casos antes, que eles acarretem grande risco à vida dos pacientes.

Introduction: descending necrotizing mediastinitis (DNM) is a severe infectious process of the mediastinum and may originate from an odontogenic infection; having a high mortality rate. The dentist should seek strategies to prevent infections that spread through the cervicofacial and thoracic spaces. Objective: to report a case of a patient with a diagnosis of DNM after Ludwig's angina, to describe its clinical manifestations and the adopted dental treatment. Case report: a thirty-one year old male patient was admitted with painful 3.8 tooth symptoms that evolved to swelling in the cervical regions, associated with fever and progressive dysphagia. Extraoral physical examination shows signs of spread to the cervicofacial and thoracic spaces. After further examination, the diagnosis was DNM associated with Ludwig's angina secondary to pericoronitis. Treatment was intravenous analgesia and antibiotic therapy. After remission of symptoms, the patient was discharged from hospital in good condition and 3.8 tooth extraction. Conclusion: DNM is a rare condition that can lead to death if not treated properly. The dentist should be aware of the possibility of spreading through the facial and mediastinal spaces of infectious processes of odontogenic origin, being able to correctly treat the cases, before they pose a great risk to patients' lives.

Angina de Ludwig em paciente portador de esquizofrenia: relato de caso / Ludwig's angina in a bearer of schizophrenia patient: case report

Introdução: Angina de Ludwig é um processo de celulite severa, quase sempre de origem odontogênica, que envolve bilateralmente os espaços perimandibulares. Objetivo: discutir o manejo da Angina de Ludwig em paciente comprometido sistemicamente em uma situação de urgência. Relato de caso: paciente L.H.S.A., 36 anos, portador de esquizofrenia, apresentou-se à emergência do Hospital Geral do Estado cursando com disfagia, dispneia e aumento de volume endurecido e aquecido à palpação em região submandibular bilateral, sublingual e submentoniana. Foi iniciado regime de antibioticoterapia venosa e encaminhamento ao centro cirúrgico para remoção do foco causal, incisão e dissecação romba profunda, bem como inserção de drenos rígidos sob anestesia geral. Resultados: aproximadamente um mês após a intervenção inicial, o paciente apresentou remissão da infecção e segue sem recidivas. Conclusão: a suspeita clínica de Angina de Ludwig deve ser aumentada em pacientes psiquiátricos e usuários de drogas psicotrópicas, uma vez que essas condições aumentam a suceptibilidade à infecção. A preservação das vias aéreas, antibioticoterapia e o tratamento cirúrgico são eficazes na erradicação do quadro.

Introduction: Ludwig's angina is a process of severe cellulitis, usually of odontogenic origin, which involves bilaterally the perimandibular spaces. Objective: to discuss the treatment of Ludwig's angina in a systemically compromised patient in an emergency. Case report: patient L.H.S.A., 36 years old, carrier of schizophrenia, reported to the emergency of the State General Hospital presenting dysphagia, dyspnea, and increased volume of hardened and warm palpation in the submandibular bilateral, sublingual and submental regions. The team started a venous antibiotic therapy regimen and sent the patient to the surgical center for removal of the causal focus, incision and deep blunt dissection, as well as insertion of rigid drains under general anesthesia. Results: about a month after the initial intervention, the patient presented remission of the infection and follows without relapses. Conclusion: the clinical suspicion of Ludwig's angina should be increased in psychiatric patients and users of psychotropic drugs, since these conditions increase the susceptibility to infection. Airway preservation, antibiotic therapy and surgical treatment are effective in eradicating the disease.

Paciente acometido por Angina de Ludwig com grave progressão reabilitado com próteses dentárias: relato de caso / Pacient affected by Ludwig's Angina with serious progression rehabilitated with dental prosthetics: case report / Paciente acometido por Angina de Ludwig con grave progresión rehabilitado con prótesis dentales: reporte de caso

O objetivo deste trabalho é relatar e discutir um caso clínico de um paciente acometido por Angina de Ludwig que evoluiu gravemente para mediastinite. O paciente compareceu inicialmente ao Pronto Socorro do Hospital Universitário da Universidade Estadual de Londrina e após diagnóstico de Angina de Ludwig foi internado e tratado de forma emergencial. O tratamento foi multiprofisssional e constituiu-se em abordagem cirúrgica para descompressão dos tecidos, administração de antimicrobianos e remoção da causa da infecção. Mesmo após a primeira abordagem cirúrgica, o paciente evoluiu gravemente e houve a necessidade de reabordagem da região cervical e torácica. O paciente necessitou de um mês de internação hospitalar até que o quadro infeccioso fosse estabilizado. Após o incidente, o paciente se apresentava com baixa autoestima e com sua relação interpessoal afetada. Desta forma, foi encaminhado para a Clínica Odontológica Universitária da Universidade Estadual de Londrina onde foi reabilitado com prótese total superior e prótese parcial removível inferior a fim de devolver grande parte da função mastigatória, estética e, consequentemente, qualidade de vida(AU)

The purpose of this study is to report and discuss a case of a patiente affected by Ludwig's angina that progressed severely to mediastinitis. The patient attended the Emergency Room at the University Hospital, State University of Londrina, and was admitted and treated in an emergencial manner. The treatment was multiprofessional and consisted in a surgical approach for tissue descompression, antibiotic administration and removal of the infection origin. Even after the first surgical approach, his clinical condition deteriorated and a new surgical intervention was necessary. The patient needed a 30-day hospital stay until the infection stabilization. After the incident, the patient had low self-esteem and his interpersonal relatioships were affected. Therefore, he was referred to the University Dental Clinic of the State University of Londrina where he was rehabilitated with an upper total prosthesis and a lower removable partial prosthesis. Treatment was able to recover masticatory and aesthetic funtion, and consequently, life quality(AU)

El objetivo de este trabajo es relatar y discutir un caso clínico de un paciente acometido por Angina de Ludwig que evolucionó gravemente a una mediastinitis. El paciente asistió al Pronto Socorro del Hospital Universitario de la Universidad Estatal de Londrina y tras el diagnóstico de Angina de Ludwig fue internado y tratado emergencialmente. El tratamiento fue multiprofesional y se constituyó en un abordaje quirúrgico para la descompresión de los tejidos, administración de antimicrobianos y eliminación de la causa de la infección. Incluso después del primer abordaje quirúrgico, el paciente evolucionó gravemente y hubo la necesidad de nueva abordaje de la región cervical y torácica. El paciente necesitó de un mes de internación hospitalaria hasta que el cuadro infeccioso se estabilizara. Después del incidente, el paciente se presentaba con baja autoestima y con sus relaciones interpersonales afectadas. De esta forma, fue encaminado a la Clínica Odontológica Universitaria de la Universidad Estadual de Londrina donde fue rehabilitado con prótesis total superior y prótesis parcial removible inferior a fin de devolver gran parte de la función masticatoria, estética y, consecuentemente, calidad de vida(AU)

Angina de ludwig: reporte de un caso en tolima, colombia / Ludwig's angina: case report in tolima, colombia

La angina de Ludwig es una patología de origen infecciosa que afecta principalmente el suelo de la boca, avanzando hacia los espacios submandibulares, sublinguales y submentonianos, progresando hacia la vía aérea, pudiendo causar su colapso, falla ventilatoria y muerte. Se realiza una revisión corta actual de la más reciente literatura acerca de esta patología. Se presenta paciente femenina adulta mayor que ingresa al servicio de urgencias con diagnóstico de celulitis en región facial. Es valorada por el médico internista de turno, quien rápidamente diagnostica la Angina de Ludwig, instaura tratamiento antibiótico de amplio espectro e interconsulta con cirugía general por posible falla ventiladora con vía aérea de difícil acceso. Gracias al rápido y oportuno diagnóstico se instauró el manejo adecuado y fue posible contener la patología sin complicaciones graves.

Ludwig's Angina is an infectious disease that affects mainly the floor of the mouth, progressing through submandibular, sublingual and submentonian spaces, making its way to the airway, being able to cause its collapse, thus causing ventilatory failure and death. First of all, we begin with a short review of the latest literature regarding this illness. Its presented an elderly female adult, who is brought into the emergency service with a face cellulitis diagnose. She is examined by the internist specialist on shift, who rapidly diagnoses Ludwig's Angina, establishes broad spectrum antibiotic treatment and interconsults with the general surgery service due to possible ventilatory failure with and a hard to access air way.Thanks to the rapid and timely diagnose an adequate treatment is established and it is possible to contain this pathology without grave complications.

Airway management in Ludwig's angina - a challenge: case report / Manejo da via aérea na angina de Ludwig - um desafio: relato de caso

Abstract Background Ludwig's angina (LA) is an infection of the submandibular space, first described by Wilhelm Frederick von Ludwig in 1836. It represents an entity difficult to manage due to the rapid progression and difficulty in maintaining airway patency, a major challenge in medical practice, resulting in asphyxia and death in 8-10% of patients. Objective Describe a case of a patient with Ludwig's angina undergoing surgery, with emphasis on airway management, in addition to reviewing the articles published in the literature on this topic. Case report Male patient, 21 years, drug addict, admitted by the emergency department and diagnosed with LA. Difficult airway was identified during the anesthetic examination. In additional tests, significant deviation from the tracheal axis was seen. Undergoing bilateral thoracoscopic pleural drainage, we opted for airway management through tracheal intubation using fiberoptic bronchoscopy, and balanced general anesthesia was proposed. There were no complications during the surgical-anesthetic act. After the procedure, the patient remained intubated and mechanically ventilated in the intensive care unit. Conclusions Airway management in patients with Ludwig's angina remains challenging. The choice of the safest technique should be based on clinical signs, technical conditions available, and the urgent need to preserve the patient's life.

Resumo Justificativa A angina de Ludwig (AL) constitui uma infecção do espaço submandibular, primeiramente descrita por Wilhelm Frederick von Ludwig em 1836. Representa uma entidade de difícil manejo devido à rápida progressão e dificuldade na manutenção da via aérea pérvia, um importante desafio na prática médica, que culmina em asfixia e morte em 8-10% dos pacientes. Objetivo Descrever o caso clínico de um paciente com angina de Ludwig submetido a procedimento cirúrgico, com ênfase no manejo da via aérea, além de revisar os artigos disponíveis na literatura médica a respeito desse tema. Relato de caso Paciente masculino, 21 anos, drogadito, admitido pelo pronto socorro e diagnosticado com AL. Na propedêutica anestésica constatou-se via aérea difícil. Nos exames complementares foi possível observar importante desvio do eixo traqueal. Submetido à toracoscopia bilateral com drenagem pleural, optou-se pelo manejo da via aérea através de intubação nasotraqueal por fibrobroncoscopia e foi proposta anestesia geral balanceada. Não houve intercorrência durante o ato cirúrgico-anestésico. Após procedimento paciente permaneceu intubado e em ventilação mecânica na Unidade de Terapia Intensiva. Conclusões O manejo da via aérea nos pacientes com angina de Ludwig permanece desafiador. A escolha da técnica mais segura deve ser embasada no quadro clínico, nas condições técnicas disponíveis e na necessidade premente de preservação da vida do paciente.

Use of the TotalTrack VLM for emergent endotracheal intubation in predicted difficult airway with obstruction by expanding space-occupying lesions and reduced interincisor opening. / Uso del TotalTrack VLM para intubación endotraqueal urgente en vía aérea difícil prevista con obstrucción por lesiones ocupantes de espacio y distancia interdental reducida.

Acute cervical pathology may lead to serious airway compromise resulting from anatomical distortion secondary to obstruction or deviation of the upper airway, scenarios where any airway device can be fallible. Passage of a fiberoptic bronchoscopy to expose the glottis may be very difficult and tracheostomy may be impractical or risky in advanced cases. We present the use of the TotalTrack VLM to secure the airway for emergent surgery in 2 uncooperative patients with difficult airway due to Ludwig's angina and neck hematoma, respectively, both accompanied by trismus.

[Airway management in Ludwig's angina - a challenge: case report]. / Manejo da via aérea na angina de Ludwig ­ um desafio: relato de caso.

BACKGROUND: Ludwig's angina (LA) is an infection of the submandibular space, first described by Wilhelm Frederick von Ludwig in 1836. It represents an entity difficult to manage due to the rapid progression and difficulty in maintaining airway patency, a major challenge in medical practice, resulting in asphyxia and death in 8-10% of patients. OBJECTIVE: Describe a case of a patient with Ludwig's angina undergoing surgery, with emphasis on airway management, in addition to reviewing the articles published in the literature on this topic. CASE REPORT: Male patient, 21 years, drug addict, admitted by the emergency department and diagnosed with LA. Difficult airway was identified during the anesthetic examination. In additional tests, significant deviation from the tracheal axis was seen. Undergoing bilateral thoracoscopic pleural drainage, we opted for airway management through tracheal intubation using fiberoptic bronchoscopy, and balanced general anesthesia was proposed. There were no complications during the surgical-anesthetic act. After the procedure, the patient remained intubated and mechanically ventilated in the intensive care unit. CONCLUSIONS: Airway management in patients with Ludwig's angina remains challenging. The choice of the safest technique should be based on clinical signs, technical conditions available, and the urgent need to preserve the patient's life.

Angina de Ludwig com evolução para mediastinite. Relato de Caso / Ludwig's Angine with Evolution to Mediastinitis. Case Report.

A angina de Ludwig (AL) é um processo infeccioso agudo e grave que consiste em uma celulite do tecido conectivo cervical que acomete bilateralmente os espaços perimandibulares (submandibular, sublingual e submentoniano). Sua natureza é polimicrobiana, normalmente de origem dentária ou relacionada a extrações dentárias em pacientes imunologicamente comprometidos ou em condições debilitantes. Possui evolução rápida e pode invadir subitamente os espaços fasciais ou bainhas vasculares e disseminar para a região cervical, obstruindo as vias aéreas. A progressão da doença pode atingir o mediastino comprimindo o coração e os pulmões, provocar insuficiência respiratória grave e evoluir para quadros sépticos extremamente severos e exigem medidas emergenciais como a traqueostomia, drenagem do abscesso e dos inúmeros focos, drenagem cirúrgica torácica aberta, hidratação do paciente e uma terapia antimicrobiana que atinja tanto os germes gram-positivos e gram-negativos, bem como os anaeróbios. Este artigo apresenta um caso de angina de Ludwig com evolução para mediastinite que foi necessário a utilização de toracotomia e traqueostomia como conduta auxiliar de controle... (AU)

The Ludwig's angina is an acute and severe infectious process of a cellulitis cervical connective tissue that affects the bilateral submandibular perimandibulares spaces, sublingual and submental). Its nature is polymicrobial, usually of dental origin or related to dental extractions in immunologically compromised patients or debilitating conditions. Has rapidly evolving and can suddenly invade the fascial spaces or vascular sheaths and spread to the neck, blocking the airway. Disease progression can reach the mediastinum compressing the heart and lungs, causing severe respiratory failure and evolve into extremely severe sepsis and require emergency measures such as tracheotomy, abscess drainage and numerous pockets, open chest surgical drainage, the patient's hydration and an antimicrobial therapy which achieves both gram-positive and gram-negative bacteria and anaerobes. This article presents a case of Ludwig's angina with evolution to mediastinitis that the use of thoracotomy and tracheostomy to conduct assist control was needed... (AU)

Angina de Ludwig. Presentación de un caso / Ludwig’s angina. Case presentation

La angina de Ludwig es una enfermedad de causa infecciosa que afecta fundamentalmente al suelo de la boca. Se produce esencialmente por abscesos de segundo y tercer molar; tiene un comienzo insidioso, por lo que se debe pensar en ella, ya que de retrasarse el diagnóstico puede tener consecuencia fatales Las complicaciones más graves son la obstrucción de la vía aérea superior, edema de la glotis y mediastinitis descendente. Su tratamiento se basa en tres pilares esenciales, dados por medidas generales, tratamiento antibiótico y quirúrgico.

Ludwig’s angina is an infection-caused disease mainly affecting the floor of the mouth. It is essentially produced by second and third molar abscesses; it has an insidious beginning, so it has to be always taken into account because if it is diagnosed late, it may have fatal consequences. The most serious complications are the obstruction of the high air ways, glottis edema and descendant mediastinitis. The treatment is based in three essential supports, given by general measures, antibiotic and surgical treatment.

Angina de Ludwig: presentación de un caso / Ludwigs angina: case presentation

La angina de Ludwig es una enfermedad de causa infecciosa que afecta fundamentalmente al suelo de la boca. Se produce esencialmente por abscesos de segundo y tercer molar; tiene un comienzo insidioso, por lo que se debe pensar en ella, ya que de retrasarse el diagnóstico puede tener consecuencia fatales Las complicaciones más graves son la obstrucción de la vía aérea superior, edema de la glotis y mediastinitis descendente. Su tratamiento se basa en tres pilares esenciales, dados por medidas generales, tratamiento antibiótico y quirúrgico(AU)

Ludwigs angina is an infection-caused disease mainly affecting the floor of the mouth. It is essentially produced by second and third molar abscesses; it has an insidious beginning, so it has to be always taken into account because if it is diagnosed late, it may have fatal consequences. The most serious complications are the obstruction of the high air ways, glottis edema and descendant mediastinitis. The treatment is based in three essential supports, given by general measures, antibiotic and surgical treatment(AU)